National Reference Laboratory for Veterinary Toxicology

1. NRL experts

• NRL coordinator

  Ch. Bianu Elisabeta, PhD in medical sciences, veterinary medicine speciality
  tel. 0374.322.075 / 0374.322.081
  e–mail: elisabeta.bianu@idah.ro

• NRL deputy coordinator

  Ch. Nica Daniela, PhD in biology

• Team working

  Ch. Ţoca Cristina, PhD candidate
  Ch. Panchiosu Adriana-Constanţa
  Dr. Dragoş Daniela, post-university studies in veterinary laboratory diagnosis
  Dr. Tudoran Cristina

2. Correspondent Community Reference Laboratory

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3. Specific atributions

• The specialists working in this NRL have the responsibility for drawing up the handbook „Manual for Veterinary Toxicological Diagnosis”.
• They also perform the changes and/or supplements for „Manual for Veterinary Toxicological Diagnosis” in accordance with new provisions of Community law and new recommendations of the World Animal Health Organization, established in „Manual of Diagnostic Tests and Vaccines for Terrestrial Animals” and „Terrestrial Animal Health Code”.
• NRL experts approve the results of validity studies proving the reliability of methods/assays used in Romania for veterinary toxicological diagnosis.
• The experts coordinate pre-taking and drawing up the standards and methods for veterinary toxicological diagnosis in Romania.
• They carry out researches activities, assimilate and draw up the new analytical methods for veterinary toxicological diagnosis.
• They participate, to the international inter-comparison and proficiency tests organized by international accredited institutions in the field.
• They participate to the quality assurance activities and method standardization for veterinary toxicological, organized by international accredited institutions in the field.
• The NRL specialists collaborate with international accredited institutions in the field and benefit from training organized by these and supplying diagnostic standards, methods or reagents for veterinary toxicological diagnosis.
• The NRL experts collaborate with international accredited organizations in the field, in order to improve the diagnostic capacity for veterinary toxicological diagnosis.
• In accordance with provisions of Diagnosis Manual, they carry out the laboratory tests/assays for veterinary toxicological diagnosis.
• The NRL experts supply the veterinary toxicological diagnosis expertise in case of positive, suspect and inconclusive results obtained by the sanitary veterinary and food safety county laboratories, and of Bucharest, respectively.
• The NRL experts supply the veterinary toxicological diagnosis expertise in case of dispute settlement.
• The NRL experts check and certify the diagnosis value of all diagnosis reagent batches and diagnosis sets or kits for veterinary toxicological diagnosis and designate their use by state sanitary veterinary laboratories from Romania.
• In preparation for yielding certain diagnosis reagents for veterinary toxicological diagnosis, supplying them for all authorised sanitary veterinary and food safety laboratories.
• They coordinate the drawing up of diagnosis standards and methods for veterinary toxicological diagnosis used by all authorized sanitary veterinary and food safety laboratories.
• The NRL experts perform the annual inter-laboratory comparative tests for checking the diagnostic capability for veterinary toxicological diagnosis, for all authorized sanitary veterinary and food safety county laboratories from county sanitary veterinary and food safety directorates.
• NRL also organize training and continuous training activities, in order to teach the specialists working in the authorized sanitary veterinary and food safety laboratories, on carrying out veterinary toxicological diagnosis.
• The NRL experts carry out specific activities for identification and characterization the toxicological factors or toxic substances causing specific intoxications or disturbing animal health status.
• They preserve, under maximum safety conditions, counter-samples in case of occurring intoxications already solved.
• The experts from NRL participate to the authorization of sanitary veterinary and food safety laboratories; they write down the checking files and assessment report and verify the achievement of quality insurance system conditions.
• Periodically, they communicate to the European Commission the list of authorized and accredited institutions or sanitary veterinary and food safety laboratories, having specific competences for veterinary toxicological diagnosis and also to notify any changes of the list.
• The NRL experts communicate, with the agreement of National Sanitary Veterinary and Food Safety Authority, the information requested by European Commission, World Animal Health Organization and other international accredited organizations and institutions in the field.
• The NRL experts provide, to National Sanitary Veterinary and Food Safety Authority and to sanitary veterinary and food safety county directorates, and of Bucharest, respectively, the official information on veterinary toxicological diagnosis with the aim of establishing the national strategies and policies on veterinary toxicological diagnosis.
• As a second or third part, they carry out advising activities, they grant technical advice and also they perform audit activities for institutions and organizations in animal husbandry or for those enterprises of which activities involve products or by-products derived from animals.
• In accordance with legislation in force, NRL promotes and implements the Good Laboratory Practice principles (GLP), to be used for applied research studies.
• They also participate to the drawing up, coordination, monitoring and carrying out some actions stipulated by “Programme for surveillance, prevention and control of animal diseases, those transmitted from animals to humans, animal and environmental protection”, yearly approved by National Sanitary Veterinary and Food Safety Authority President’s order.
• They participate to the establishing of maximum number of samples which are to be sampled for laboratory exams, regarding veterinary toxicological diagnosis and the maximum number of samples for laboratory exams done on pool samples.
• They participate to the elaboration of law drafts for veterinary toxicological diagnosis.
• They also participate to design the technical programs, the national and international projects regarding veterinary toxicological diagnosis.
• The NRL experts participate or manage the research activities of national or international research programmes.

4. Activity in relation with correspondent Community Reference Laboratory

• Attendance to workshops
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• Attendance to trainings
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• Participation to the international inter–comparison and proficiency tests
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5. Activity in relation with correspondent national reference laboratories from Member States

• Attendance to workshops
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• Attendance to trainings
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• Participation to the international inter–comparison and proficiency tests
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6. Activity in relation with correspondent international reference laboratory

• Attendance to workshops
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• Attendance to trainings
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• Participation to the international inter–comparison and proficiency tests
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7. Activity in relation with other international accredited institutions in the field

• Attendance to workshops
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• Attendance to trainings
  • 1996 - Veterinary Drug Residues and Pesticides Residues Analysis, organized by National Institute of Health, Spanish Health Ministry, Madrid, Spain
  • 1996 - Environmental toxicology, organized by Centro de Investigation en Sanidad Animal, Valdeolmos, Spain
  • 1999 - Analytical methods for determination of pesticides and heavy metals in food and feed, organized by Instituto Zooprofilattico Sperimentale, Teramo, Italy
  • 2000 - Good laboratory practice, organized by Agence Francaise de Securite Sanitaire des Aliments, Nisa, France
  • 2002 - Doping control agents in race horses, organized by National Veterinary Institute Uppsala, Sweden
  • 2002 - Analytical methods used in veterinary toxicology, organized by Animal Health Service, Deventer, Netherlands
  • 2003 - Nitrofurans and their metabolites, organized by Joint Research Centre, Institute for Reference Materials and Measurements, Geel, Belgium
  • 2003 - Analytical methods for identification of toxins in honey, organized by Centre apicole de recherche et d'information, Louvain la Neuve, Belgium
  • 2004 - Analytical methods used in ecotoxicology field, organized by INIA, Department of the Environment, Laboratory for Ecotoxicology, Madrid, Spain
  • 2004 - Analytical methods for the identification of pesticides residues in honey, organized by Niedersächsisches Landesinstitut für Bienenkunde, Celle, Germany
  • 2006 - 1st Balkan Waters HPLC-MS School, Belgrad, Serbia
  • 2008 - Rapid tests – marine toxins, cyanotoxins, mycotoxins, histamine and antibiotics, organized by AOAC International, Seattle, USA
  • 2008 - Measurement uncertainty. Practical examples, organized by AOAC International, Tacoma, USA
  • 2008 - Use of reference materials and the estimation of measurement uncertainty, organized by European Commission, JRC, Institute for Reference Materials and Measurements, Geel, Belgium
  • 2008 - The complete GC Course, organized by Royal Chemical Society Cambridge, Berlin, Germany
  • 2009 - Mass Spectrometry and Proteomics, organized by Syddansk University, Odense, Denmark, 2009
• Participation to the international inter–comparison and proficiency tests
  • 2008 - Determination of cadmium and lead in herbal samples, Proficiency testing programme TO65, Asia Pacific Laboratory Acreditation Cooperation APLAC

8. Activity in relation with counties SVFSLs

• Workshop organization
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• Training organization
  • 2006 - Chemical methods used in veterinary toxicology
  • 2006 - Quality control system implementation. Introduction in chemical methods validation
  • 2006 - Guidance for laboratory specialist in veterinary toxicology diagnosis
  • 2006 - Quality control system implementation for chemical laboratories. Methods validation. Measurement uncertainty assessment
  • 2007 - Chemical methods used in veterinary toxicology
  • 2007 - Guidance for laboratory specialist in veterinary toxicology diagnosis
  • 2007 - Quality control system implementation for chemical laboratories. Methods validation. Measurement uncertainty assessment
  • 2008 - Chemical methods used in veterinary toxicology
  • 2008 - Laboratory veterinarian specialist approach for veterinary toxicology diagnosis
  • 2008 - Quality control system for chemical laboratories. Control charts
  • 2008 - Atomic absorption spectrometry
• Performing inter–comparison and proficiency tests
  • 2005 - Sodium chloride determination in brain samples
  • 2006 - Monensin determination in feedingstuffs samples
  • 2006 - Carbofuran identification in gastric content samples
  • 2007 - Animal feeding stuffs - determination of easily hydrolysed nitrogen
  • 2007 - Strychnine identification in stomach content samples
  • 2008 - Determination of water soluble chlorides content in feedingstuffs samples
  • 2008 - Phosphides identification in gastric content samples
  • 2009 - Nitrites determination in feedingstuffs samples
  • 2009 - Kreiss reaction for fat in feedingstuffs

9. Activity in relation with other institutions than SVFSLs or legal and private person

• Workshop organization
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• Training organization
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• Performing inter–comparison and proficiency tests
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